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    Association details:
    Biomarker:HSPB1 expression
    Cancer:Melanoma
    Drug:Avastin (bevacizumab) (VEGF-A inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    PLoS One
    Title:

    Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study

    Excerpt:
    ...findings suggest that strong HSP27 expression in melanoma metastases predicts response to bevacizumab treatment.
    DOI:
    10.1371/journal.pone.0155242