^
Association details:
| Biomarker: | HSPA5 overexpression |
|---|---|
| Cancer: | Brain Cancer |
| Drug Class: | CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
Published date:
11/21/2023
Excerpt:
We show that GRP78 is highly expressed on the cell surface of multiple solid and brain tumors...We demonstrate that GRP78-CAR T cells can recognize and kill GRP78+ brain and solid tumors in vitro and in vivo.
DOI:
10.1016/j.xcrm.2023.101297
