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Association details:
| Biomarker: | HRD |
|---|---|
| Cancer: | Prostate Cancer |
| Drug Class: | PARP inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
267P - Exploring homologous recombination deficiency threshold for predicting response to PARP inhibitor in prostate cancer
Published date:
11/27/2023
Excerpt:
In the 12 patients who received PARPi in our cohort, 8 patients with a high HRD score achieved a disease control rate of 83.3%. In addition, 4 patients with a low HRD score but with mutations in HRR genes other than BRCA1/2 achieved a disease control rate of 25.0%....HRD positive, defined as GIS score >9, may be an appropriate threshold to predict the likelihood of response to PARPi in prostate cancer.