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Association details:
| Biomarker: | HRD |
|---|---|
| Cancer: | Mantle Cell Lymphoma |
| Drug: | LP-284 (Alkylating agent, DNA repair enzyme inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting Homologous Recombination Deficiencies in B‑Cell Non‑Hodgkin Lymphomas With the Novel Anti‑Tumor Small Molecule LP‑284
Published date:
09/01/2023
Excerpt:
...we investigated LP-284’s in vivo efficacy in an HRD mantle cell lymphoma cell line-derived xenograft mouse model. We observed 97% tumor growth inhibition (TGI) and no significant weight changes (P>.05) compared with the vehicle-treated mice.
