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Association details:
| Biomarker: | HRD |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of cancer hallmarks associated with benefit in advanced gastroesophageal adenocarcinoma patients treated with checkpoint blockade.
Published date:
01/23/2020
Excerpt:
Patients selected by only using CIN & HRD had significant improvement in OS (HR = 0.63; p= 0.03)….GES representing HRD and activation of HER2, EGFR and MAPK (each enriched in CIN) were associated with improved survival upon checkpoint blockade in advanced GEA patients.
Trial ID:
