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Association details:
| Biomarker: | HRD |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | saruparib (AZD5305) (PARP1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2794 / 17 - A Quantitative Systems Pharmacology (QSP) model to characterize dose-dependent antitumor activity of AZD5305, PARP1 selective inhibitor, across multiple xenograft models
Published date:
03/15/2023
Excerpt:
Xenograft models with HRR deficiency such as HBCx-17, DLD-1 BRCA2 KO and MDA-MB-436 (with a very low khrr) were the most sensitive to AZD5305 and treatment led to tumor regressions.
