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Association details:
| Biomarker: | HRAS mutation |
|---|---|
| Cancer: | Bladder Cancer |
| Drug: | FL118 (DDX5 degrader) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Role of mutant KRAS as a biomarker in FL118-induced apoptosis, reactive oxygen species (ROS) production and inhibition of survivin, Mcl-1 and XIAP in human bladder cancer.
Published date:
05/28/2020
Excerpt:
...FL118, an innovative small molecule, exhibits differential anticancer efficacy in high-grade bladder cancer cell lines (HT1376, T24, UMUC-3). FL118 is highly effective at inhibiting the viability of T24 and UMUC-3 bladder cancer cells, which have Hras and Kras mutations...mutant Kras appeared to be involved in FL118 efficacy and played a positive role in mediating FL118 effects.
DOI:
10.1200/JCO.2020.38.15_suppl.e15651
