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Association details:
| Biomarker: | HRAS G13R |
|---|---|
| Cancer: | Thyroid Gland Carcinoma |
| Drug: | FRAX597 (P21-activated kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
Excerpt:
...we explored growth in response to AZD6244, FRAX597, or their combination in C643 cells (HRASG13R, NF2-WT)with or without merlin silencing. Consistent with the data shown in Fig. 6, C643-shNF2.M2 cells are exquisitely sensitive to the MEK inhibitor. Although knockdown of merlin also sensitizes cells to growth inhibition by the PAK inhibitor, the effects were comparatively modest. Combined inhibition showed only modest additive effects...
DOI:
10.1158/2159-8290.CD-15-0330
