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    Association details:
    Biomarker:HRAS G13R
    Cancer:Thyroid Gland Anaplastic Carcinoma
    Drug:CI-1040 (MEK inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Endocrine Society
    Title:

    Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells with BRAF or RAS Mutations

    Excerpt:
    Genotypes of various thyroid cancer cell lines and their sensitivity to inhibition by CI-1040.
    DOI:
    https://doi.org/10.1210/jc.2007-0097