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Association details:
| Biomarker: | HR positive |
|---|---|
| Cancer: | Hormone Receptor Positive Breast Cancer |
| Drug: | ST101 (CEBPB antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
Excerpt:
...HR positive LA/MBC, melanoma, GBM, CRPC 5....
Trial ID:
Source:
Title:
959-C/EBPß antagonist peptide, ST101, as a therapeutic approach in breast cancer
Published date:
03/10/2021
Excerpt:
In vitro studies in 4T1-luc triple-negative breast cancer (TNBC) and MCF7 HRPOS breast adenocarcinoma cells demonstrate ST101 dose-dependent impact of cell viability (EC50 of 4.8 and 2.1 µM, respectively)...Mice treated with 25 mg/kg ST101 via subcutaneous injection demonstrated significant tumor growth delay and decrease in tumor volume vs. controls. These data emphasize the potential of ST101 as a potent peptide therapeutic for HRPOS and TN BC.
