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    Association details:
    Biomarker:HOXC8 overexpression
    Cancer:Hepatocellular Cancer
    Drug:oxaliplatin (DNA synthesis inhibitor, DNA cross linking agent)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    Dig Dis Sci
    Title:

    Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma

    Excerpt:
    HOXC8 siRNA knockdown delayed the G1–S phase transition, inhibited cell proliferation, and attenuated resistance to oxaliplatin....Furthermore, upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.
    DOI:
    https://doi.org/10.1007/s10620-015-3774-x