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Association details:
| Biomarker: | HMOX1 overexpression |
|---|---|
| Cancer: | Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1777P - HEME catabolism in peripheral monocytes and response to immune checkpoint inhibitors in advanced lung cancer
Published date:
09/13/2021
Excerpt:
A Cox proportional hazard model showed that higher HO-1 levels in classical monocytes were associated with a trend for a lower risk of progression rate at 6 months (HR 0.60, 95%CI 0.18 – 2.07). These preliminary results suggest that in lung cancer patients treated with ICIs higher levels of HO-1 in classical monocytes have a protective role and are associated with an improved outcome.