^
Association details:
| Biomarker: | HMGA1 overexpression |
|---|---|
| Cancer: | Soft Tissue Sarcoma |
| Drug: | Yondelis (trabectedin) (Alkylating agent, DNA inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Prognostic role of HMG proteins in a series of 301 advanced soft tissue sarcoma patients: A Spanish Group for Sarcoma Research Study (GEIS).
Published date:
05/16/2018
Excerpt:
Strong expression of HMGA1 showed significant worse prognosis for OS from M1 time (31 vs 22 m; p = 0.007) and for PFS of trabectedin line (3.8 vs 2.6 m; p = 0.002). Similar results were obtained with high HMGA1 expression.
DOI:
10.1200/JCO.2018.36.15_suppl.11573
