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Association details:
| Biomarker: | HLA-E overexpression + TMB-L |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Distinct Functional Metagenomic Markers Predict the Responsiveness to Anti-PD-1 Therapy in Chinese Non-Small Cell Lung Cancer Patients
Published date:
04/21/2022
Excerpt:
We followed a Han Chinese cohort of 85 advanced non-small cell lung cancer (NSCLC) patients, who received anti-PD-1 antibodies....In our data, patients with a high expression level of HLA-E (HLA-B rs1050458 Met/Thr or Met/Met) combined with low TMB (n = 6) exhibited the shortest PFS...
DOI:
10.3389/fonc.2022.837525
