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Association details:
| Biomarker: | HLA-DRA expression |
|---|---|
| Cancer: | Melanoma |
| Drug: | IMMU-140 (Topoisomerase I inhibitor, HLA-DR-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
IMMU-140, a Novel SN-38 Antibody–Drug Conjugate Targeting HLA-DR, Mediates Dual Cytotoxic Effects in Hematologic Cancers and Malignant Melanoma
Excerpt:
...mice bearing HLA-DRpos melanomas (A-375) were treated with IMMU-140 (Fig. 3D). Only mice treated with IMMU-140 demonstrated a significant antitumor effect when compared with all other groups (P < 0.0244; Supplementary Table S1).
DOI:
https://doi.org/10.1158/1535-7163.MCT-17-0354
