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Association details:
| Biomarker: | HK2 overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | daunorubicin (Topoisomerase II inhibitor, DNA intercalator) |
| Direction: | Resistant |
Evidence:
Source:
Title:
3098 - Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Published date:
03/10/2021
Excerpt:
we explored the DNA damage response in AML LSCs to investigate if enhanced DNA repair contributes to relapse and chemoresistance....Over-expression of nuclear HK2 also conferred resistance to daunorubicin as measured by clonogenic growth assays.
