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Association details:
Biomarker:High MHC-II signature
Cancer:Bladder Cancer
Drug:NU7441 (DNA PK inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

MHC-II Signature Correlates With Anti-Tumor Immunity and Predicts anti-PD-L1 Response of Bladder Cancer

Published date:
02/11/2022
Excerpt:
...we divided the patients into MHC-H and MHC-L groups according to the median level of the MHC-II signature score of all samples....The IC50 values of Cisplatin, Docetaxel, Sunitinib, and NU.7441 in the MHC-H group were significantly lower than those of the MHC-L group, and all of these values were significantly correlated with the MHC-II signature score all P < 0.001...Finally, we identified a significant increase in drug sensitivity to cisplatin, docetaxel, sunitinib and NU.7441 in the MHC-H group.
DOI:
https://doi.org/10.3389/fcell.2022.757137