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Association details:
| Biomarker: | HGF-L |
|---|---|
| Cancer: | T Acute Lymphoblastic Leukemia |
| Drug: | Poteligeo (mogamulizumab-kpkc) (CCR4 receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EPIGENETIC REGULATION OF HGF/C-MET SIGNALING PATHWAY CONFERS AGGRESSIVENESS IN LYMPH NODE ADULT T-CELL LEUKEMIA/LYMPHOMA
Published date:
05/14/2020
Excerpt:
The median PFS in 26 patients treated with Moga was 420 and 116 days, and OS was 704 and 344 days in low and high HGF groups, respectively (P=0.04 and 0.025)….Our data indicate that serum HGF levels may be a useful predictor of Moga resistance.
