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Association details:
| Biomarker: | HER-2 V773A |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
Excerpt:
Since levels of up to 1 mM of lapatinib may be achieved in patients, ERBB2-V773A, ERBB2-T862A and ERBB2-N857S (IC90 approximately 0.5 mM) mutations might respond to higher doses of lapatinib.
DOI:
10.1371/journal.pone.0026760
