^
Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | SAR446309 (HER2 inhibitor, CD3 agonist, Cytotoxic T lymphocyte stimulant) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human primate (NHP)
Published date:
11/09/2020
Excerpt:
HER2-PAT demonstrated potent in vitro T-cell cytotoxicity (EC50 1-2pM) and target-dependent T-cell activation and cytokine production by hPBMCs. HER2-XPAT provided up to 14,000-fold protection against killing of HER2 tumor cells and no cytotoxicity against cardiomyocytes up to 1uM. In vivo, HER2-XPAT induced complete tumor regressions in BT-474 tumors with equimolar dosing to HER2-PAT...
DOI:
http://dx.doi.org/10.1136/jitc-2020-SITC2020.0613
