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Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | FGX15-147-based ADC (Alkylating agent, undefined TAA/TSA-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1750 / 2 - Design and development of a novel highly sequence-selective guanine mono-alkylating DNA-interactive ADC payload suitable for solid tumor treatments
Published date:
03/09/2022
Excerpt:
To explore the utility of FGX15-147 as an ADC payload, it was conjugated to trastuzumab in a stochastic manner (DAR 1.6) using a Maleimide-Valine-Alanine linker construct. The resulting ADC exhibited significant in vivo efficacy in a low copy number HER2+ pancreatic cancer Human Tumor Xenograft model using BALB-c mice transplanted with the CAPAN-1 cell line.
