Evidence Level:Sensitive: D – Preclinical
Title:
EDIT-202, a Multiplexed CRISPR-Cas12a Gene-Edited iPSC-Derived NK Cell Therapy Has Prolonged Persistence, Promotes High Cytotoxicity, and Enhances In Vivo Tumor Killing
Excerpt:EDIT-202 induced significantly enhanced anti-tumor efficacy in vivo when evaluated using a SKOV3 HER2+ ovarian cancer model.