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Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | trastuzumab-IFN-β mutein (HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1803 / 7 - GNP101, anti-HER2-IFN-β mutein immunocytokine, for the treatment of Trastuzumab deruxtecan-resistant HER2-positive cancers
Published date:
03/15/2023
Excerpt:
A panel of human HER2-positive cancer cell lines derived from breast, stomach and lung were treated with GNP101 or HER2 therapeutics (trastuzumab, T-DM1, T-DXd) to compare direct antitumor effects....GNP101 showed superior potency compared to existing HER2 therapies (trastuzumab, T-DM1, and T-DXd) in all HER2-positive cancers...The activities of GNP101, T-DM1 and T-DXd on HER2-positive cancer cells were compared in vivo. GNP101 inhibited the growth of tumor by 90%, with no difference from that of T-DXd or T-DM1.
