^
Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | Clopixol (zuclopenthixol) (DRD2 antagonist, DRD1 antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Allosteric inhibition of HER2 by Moesin-mimicking compounds targets HER2-positive cancers and brain metastases
Published date:
09/07/2021
Excerpt:
Zuclopenthixol efficiently inhibited HER2-positive breast tumor progression in vitro and in vivo and, more importantly, showed significant activity on HER2-positive brain tumor progression.
DOI:
10.1158/0008-5472.CAN-21-0162
