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Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | itraconazole (CYP51A1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
896 / 10 - An antifungal, Itraconazole, induces cell death by targeting HER2 signaling and stem-like properties in trastuzumab-resistant HER2-positive breast cancer
Published date:
03/09/2022
Excerpt:
Treatment of itraconazole significantly suppressed the growth of JIMT-1 cells with marked induction of apoptosis….We have demonstrated that itraconazole, which is FDA-approved drug as an anti-fungal drug, exerts anti-tumor activity in trastuzumab-resistant HER2-positive breast cancer by targeting cancer stem-like properties, suppression of the HER2 signaling as well as induction of autophagy.
