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Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | azacitidine (DNA methylation inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer
Excerpt:
...HER2 positive (IHC or FISH) 2....
Trial ID:
Source:
Title:
2489 / 29 - Study the efficacy of hypomethylating agent in treating regular and brain metastasized HER2-positive breast cancer
Published date:
03/15/2023
Excerpt:
Our results showed that train metastasized HER2-positive breast cancer JIMT-1 Br cells have similar growth rate compared to their parental regular breast cancer JIMT-1 cells...72 hours of AZA treatment significantly inhibited cell grow in both cell lines, and the inhibition of JIMT-1 growth is greater than that of JIMT-1 Br cells; (3) AZA triggered apoptosis in both cell lines in a dose-dependent manner; (4) Higher concentrations of AZA induced a higher percentage of cell apoptosis in JIMT-1 compared to JIMT-1 Br cells....We found that AZA inhibits cell growth and promotes apoptosis in both cell types...
