Evidence Level:Sensitive: A2 - Guideline
New
Title:
Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Excerpt:Trastuzumab is recommended in conjunction with platinum and fluoropyrimidine-based chemotherapy for patients with HER2-positive advanced gastric cancer.
DOI:10.1093/annonc/mdw350
Evidence Level:Sensitive: B - Late Trials
Title:
P-144 A comparative analysis of secondary data from the ToGA and EVIDENCE studies on the effectiveness of trastuzumab plus chemotherapy in Asian patients with HER2+ metastatic gastric cancer
Excerpt:The Chinese population (28 vs 34) from the ToGA RCT was selected for subgroup analyses; resulting outcomes were more consistent with EVIDENCE for both OS (HR, 0.554; 95% CI, 0.261–1.174) and PFS (HR, 0.599; 95% CI, 0.324–1.107)....data from the ToGA and EVIDENCE studies showed the effectiveness of trastuzumab in Asian patients with HER2+ mGC in the RCT and real-world settings, respectively.
DOI:doi.org/10.1016/j.annonc.2021.05.199
Evidence Level:Sensitive: C1 - Off-label
(Approved for Gastroesophageal Junction Adenocarcinoma)
New
Excerpt:Herceptin in combination with capecitabine or 5-fluorouracil and cisplatin is indicated for the treatment of patients with HER2-positive metastatic adenocarcinoma of the stomach or gastroesophageal junction who have not received prior anticancer treatment for their metastatic disease.
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Trastuzumab Plus Docetaxel and Capecitabine For First Line Treatment of Her2-Positive Advanced Gastric Cancer
Excerpt:...HER2 positive tumor (primary tumor or metastasis, HER2 positive as defined by IHC2+ and a confirmatory FISH+ result (HER2:CEP17 ratio ≥2), or by an IHC 3+ result) as assessed by the central laboratory....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A Study of Herceptin (Trastuzumab) in Combination With Standard Chemotherapy in Patients With HER Positive Metastatic Gastric Cancer
Excerpt:...- HER2 positive tumor (primary tumor or metastasis...
More C2 evidence
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Dose determination of Taxotere®, Eloxatin® and Xeloda® (TEX) in combination with Herpectin® as first line treatment to patients with HER2-positive non-resectable esophagus, cardia or gastric cancer
Excerpt:...HER2-positive tumor tissue (IHC 3 + or FISH positive)3. ...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A Study to Evaluate the Efficacy and Safety of Trastuzumab in Combination With Capecitabine and Oxaliplatin as First-line Chemotherapy for Inoperable, Locally Advanced or Recurrent and/or Metastatic Gastric Cancer
Excerpt:...HER2 positive tumour (primary tumour or metastasis) as assessed by the central laboratory....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
NK Cell Infusions With Trastuzumab for Patients With HER2+ Breast and Gastric Cancer
Excerpt:...Histologically confirmed diagnosis of HER2-positive breast or gastric cancer (defined as IHC 3+ or HER2 FISH amplification ratio >2.2) 3....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Combination Trastuzumab With Expanded Natural Killer Cells for Treating HER2-positive Gastric Cancer
Excerpt:...- Patients with histologically confirmed HER2 positive advanced gastric cancer through immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH); -...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A Study of Capecitabine [Xeloda] in Combination With Trastuzumab [Herceptin] and Oxaliplatine in Patients With Resectable Gastric Cancer
Excerpt:...- Locally advanced resectable HER2-positive gastric or esophagogastric junction adenocarcinoma (Sievert types I, II, III)...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Clinical study on Banxia Xiexin Decoction Combined with palliative chemotherapy in the treatment of HER2 positive advanced gastric cancer
Excerpt:...Patients with gastric cancer who met the diagnostic criteria and had positive HER-2 test and TNM stage IV; 2. ...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Concurrent Neoadjuvant Chemoradiotherapy Plus Trastuzumab in the Treatment of Siewert II, III of HER-2 Positive Gastroesophageal Junction Adenocarcinoma: A Randomized, Controlled trial
Excerpt:...The her-2 positive was detected by immunohistochemistry or FISH; 3. ...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
ctDNA Screening in Advanced HER2 Positive Gastric Cancer
Excerpt:...HER2 positive: IHC 3+ or IHC 2+ plus FISH positive, HER2 negative: IHC 0/1+ or IHC 2+ plus FISH negative....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
An Observational Study of Herceptin (Trastuzumab) in Patients With HER2-positive Advanced Gastric Cancer
Excerpt:...- HER2-positive tumor...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Trastuzumab in Combination With Capecitabine and Oxaliplatin(XELOX) in Patients With Advanced Gastric Cancer(AGC): Her+XELOX
Excerpt:...HER2 positive tumour (primary tumour or metastasis) defined as either IHC2+ and FISH+ or IHC3+ according to the gastric cancer scoring system for HER2 4....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Efficacy and Safety of Trastuzumab, Capecitabine y Oxaliplatine as Treatment Gastric Cancer Metastatic (HER2)Positive
Excerpt:...- Patients diagnosed with metastatic gastric or gastro-esophageal junction adenocarcinoma (HER2-positive), unresectable and histologically confirmed Measurable disease, following the new RECIST criteria,...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Concurrent Neoadjuvant Chemoradiotherapy Plus Trastuzumab in the Treatment of Siewert II ,III of Human Epidermal Growth Factor Receptor-2(HER-2) Positive Gastroesophageal Junction Adenocarcinoma: A Randomized, Controlled Clinical Study
Excerpt:...The her-2 positive was detected by immunohistochemistry or Fluorescence in SituHybridization(FISH);...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
T- XELOX in HER2-positive Stage III Gastric Cancer After D2 Gastrectomy
Excerpt:...HER2-positive: (IHC 3+ or IHC 2+ and FISH positive)....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Taxotere®, Eloxatin® and Xeloda® (TEX) in Combination With Herceptin® as Treatment for HER2 Positive Non-resectable Cancer
Excerpt:...HER2-positive tumor tissue (IHC 3 + or FISH positive) 3....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
PET Imaging With 89Zr-DFO-Trastuzumab in Esophagogastric Cancer
Excerpt:...- Pathologically or cytologically confirmed metastatic or primary esophagogastric cancer HER2 positive status by FISH or IHC as currently being implemented for patients with esophagogastric cancer....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Clinical Efficacy of Trastuzumab in Combination With Capecitabine and Oxaliplatin for the Treatment of HER2-positive Advanced Gastric Cancer.
Excerpt:...- HER2-positive AGC defined as either HER2 immunohistochemistry (IHC) 3+ or IHC 2+ and fluorescence in situ hybridization (FISH)+ with...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
ToGA Study - A Study of Herceptin (Trastuzumab) in Combination With Chemotherapy Compared With Chemotherapy Alone in Patients With HER2-Positive Advanced Gastric Cancer
Excerpt:...- HER2-positive tumors...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A Study of Herceptin (Trastuzumab) in Combination With Cisplatin/Capecitabine Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastric or Gastro-Esophageal Junction Cancer
Excerpt:...- HER2-positive primary or metastatic tumor as assessed by central laboratory...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Study of Margetuximab in Combination with INCMGA00012 and Chemotherapy or MGD013 and Chemotherapy in HER2-Positive Gastric or Gastroesophageal Junction Cancer
Excerpt:...Histologically confirmed diagnosis of previously untreated locally advanced unresectable or metastatic HER2+ GC or GEJ adenocarcinoma - Cohort A: HER2-positive (by IHC 3+) and PD-L1-positive (by IHC with 22C3 CPS ≥ 1%), per central review. ...
Less C2 evidence
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab deruxtecan in patients in the USA and Europe with HER2-positive advanced gastric or gastroesophageal junction cancer with disease progression on or after a trastuzumab-containing regimen (DESTINY-Gastric02): primary and updated analyses from a single-arm, phase 2 study
Excerpt:As of data cutoff for the updated analysis (median follow-up 10·2 months [IQR 5·6-12·9]), a confirmed objective response was reported in 33 (42% [95% CI 30·8-53·4]) of 79 patients, including four (5%) complete responses and 29 (37%) partial responses, as assessed by independent central review...These clinically meaningful results support the use of trastuzumab deruxtecan as second-line therapy in patients with HER2-positive advanced gastric or gastro-oesophageal junction cancer.
DOI:10.1016/S1470-2045(23)00215-2
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab combined chemotherapy for the treatment of HER2-positive advanced gastric cancer: A systematic review and meta-analysis of randomized controlled trial
Excerpt:Meta-analysis results showed that trastuzumab in combination with chemotherapy achieved better outcomes on response rate (trastuzumab plus CFC vs CFC: odds ratio [OR] = 1.56, 95% confidence interval [CI] [1.17-2.09], I2 = 0%, P < .003; trastuzumab plus OT vs OT: OR = 2.97, 95% CI [1.74-5.09], I2 = 0%, P < .0001...The results of this study revealed that the efficacy of trastuzumab combined with chemotherapy was superior to that of chemotherapy alone for the treatment of HER2-PAGC.
DOI:10.1097/MD.0000000000029992
Evidence Level:Sensitive: C3 – Early Trials
Title:
Real-world data of trastuzumab in metastatic cancer
Excerpt:We analysed the prevalence of Her2-positive metastatic gastric cancer, the overall survival (OS) and the progression-free survival (PFS) of these patients….In five of the patients the chemotherapy regimen used was the combination of 5-fluorouracil, cisplatin and trastuzumab...our median PFS (12 months) leads us to believe that much like the OS was better in the HER2-positive subgroup, so must the PFS improve in this subgroup.
Secondary therapy:cisplatin + 5-fluorouracil
DOI:https://doi.org/10.1016/j.annonc.2022.04.149
Evidence Level:Sensitive: C3 – Early Trials
Title:
Real-World (RW) United States (US) First-Line (1L) Treatment (TX) Patterns and Overall Survival (OS) of Patients (PTS) with Unresectable Advanced or Metastatic (ADV/MET) Gastric Cancer, Gastroesophageal Junction Cancer and Esophageal Adenoc ...
Excerpt:...clinical characteristics and 1L tx were described by HER2 status for adult pts diagnosed with adv/met GC/GEJC/EAC from January 2011 to December 2020...a majority (65%) of HER2+ pts received trastuzumab…. Median OS for HER2+, HER2− and HER2un pts was 12.2, 9.8 and 7.6 months, respectively.
Evidence Level:Sensitive: C3 – Early Trials
Title:
Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer
Excerpt:We evaluated the efficacy and safety of S-1 and oxaliplatin (100 mg/m2) (SOX100) combined with trastuzumab, a monoclonal antibody against HER2 for HER2-positive AGC....In the 25 patients evaluable for analysis, the 1-year survival rate was 70.8% [90% confidence interval (CI) = 55.5-86.1%], whereas the median OS, PFS, and ORR were 17.8 (95% CI 10.5-22.9) months, 7.6 (95% CI 5.0-10.9) months, and 75.0% (95% CI 53.3-90.2), respectively....SOX100 combined with trastuzumab was effective with a favorable safety profile in patients with HER2-positive AGC.
DOI:10.1007/s12029-021-00711-0
Evidence Level:Sensitive: C3 – Early Trials
Title:
Efficacy of trastuzumab and potential risk factors on survival in patients with HER2-positive metastatic gastric cancer
Excerpt:...138 patients who were given trastuzumab-based chemotherapy as first-line treatment and analyzed the relationship between clinical response rates and maintenance treatment status and survival outcomes...the median progression-free survival and overall survival were 10.2 and 16 months, respectively. Clinical response was obtained in 79% of patients. The median overall survival was 16.9 months in follow-up group and 19.0 months in the maintenance group in patients with clinical response.
DOI:10.2217/fon-2021-0398
Evidence Level:Sensitive: C3 – Early Trials
Title:
Efficacy of trastuzumab combined with SOX or IP chemotherapy regimen in the treatment of advanced gastric cancer
Excerpt:A total of 138 patients with HER-2-positive advanced gastric cancer were divided into SOX group (SOX chemotherapy regimen combined with trastuzumab; n=69) and IP group (IP chemotherapy regimen combined with trastuzumab; n=69)….The disease control rate (DCR) was clearly better in SOX group than that in IP group... the follow-up results revealed that the PFS of patients was overtly longer in SOX group than that in IP group....Trastuzumab combined with SOX chemotherapy regimen has an obvious curative effect in the treatment of advanced gastric cancer, which prominently improves the quality of life of patients, lowers the serum tumor marker levels in patients, delays tumor progression, and results in tolerable adverse reactions.
Evidence Level:Sensitive: C3 – Early Trials
Title:
Treatment patterns and outcomes in Chinese gastric cancer patients by HER2 status: a non-interventional registry study (EVIDENCE)
Excerpt:EVIDENCE was a prospective, multicenter, non-interventional registry study evaluating the safety and effectiveness of trastuzumab in five cohorts of Chinese GC patients, stratified by HER2 status and trastuzumab treatment….Respective first-line progression-free survival (PFS1) was 8.2, 6.9, and 6.2 months; and respective first-line response rates (RR) were 51.7%, 18.4%, and 32.8%....Safety profiles were consistent with those known for trastuzumab and chemotherapy; trastuzumab treatment improved outcomes.
Evidence Level:Sensitive: C3 – Early Trials
Title:
A Phase II Study of the Combination of Oxaliplatin, Capecitabine, and Trastuzumab and Chemoradiotherapy in the Adjuvant Setting in Operated Patients With HER2-positive Gastric or Gastroesophageal Junction Cancer (TOXAG Study): A Turkish Oncology Group Study
Excerpt:The patients with HER2-positive gastric, or gastroesophageal junction adenocarcinoma, after gastrectomy plus D2 dissection, were included. They received 3 cycles of oxaliplatin (100 mg/m2 intravenously day 1) plus capecitabine (850 mg/m2 orally days 1 to 14), trastuzumab (8 mg/kg intravenously day 1 in cycle 1, 6 mg/kg thereafter) every 21 days...After the 25 months follow-up period, 21 patients (61.8%) were alive. Overall survival at 12 and 24 months was 75.0% and 58.0%, while disease-free survival at 12 and 24 months was 65.7% and 55.0%, respectively.
Secondary therapy:capecitabine + oxaliplatin
DOI:10.1097/COC.0000000000000825
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data
Excerpt:This study analyzed the real-world data of 47 patients with HER2-positive RPMGC treated with trastuzumab-based chemotherapy in a single institution….With the median follow-up duration of 18.8 months in survivors, the median overall survival (OS) and progression-free survival were 12.8 and 6.9 months, respectively, and the overall response rate was 64%.
DOI:10.1186/s12885-021-08058-2
Evidence Level:Sensitive: C3 – Early Trials
Title:
Perioperative trastuzumab, capecitabine and oxaliplatin in patients with HER2-positive resectable gastric or gastro-oesophageal junction adenocarcinoma: NEOHX phase II trial
Excerpt:This Spanish, multicentre, open-label phase II trial evaluated the efficacy and toxicity of perioperative capecitabine, oxaliplatin and trastuzumab (XELOX-T) in patients with HER2-positive resectable GA or GEJA….Thirty-six patients were included....After a median follow-up of 24.1 months, 18-month DFS was 71% (95% confidence interval [CI], 53–83%); and an update after 102 months of follow-up showed a median OS of 79.9 months and a 60-month OS of 58% (95% CI, 40–73%).
DOI:10.1016/j.ejca.2020.12.005
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab ± Capecitabine Maintenance After the First-Line Treatment of HER2-Positive Advanced Gastric Cancer: Retrospective Observational Real-Life Data of Turkish Oncology Group
Excerpt:Trastuzumab maintenance ± capecitabine after 6 cycles of trastuzumab plus combined chemotherapy treatment revealed efficacy and safety in non-progressive HER2-positive advanced gastric cancer.
DOI:10.1007/s12029-021-00594-1
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab ± Capecitabine Maintenance After the First-Line Treatment of HER2-Positive Advanced Gastric Cancer: Retrospective Observational Real-Life Data of Turkish Oncology Group
Excerpt:Trastuzumab maintenance ± capecitabine after 6 cycles of trastuzumab plus combined chemotherapy treatment revealed efficacy and safety in non-progressive HER2-positive advanced gastric cancer.
DOI:10.1007/s12029-021-00594-1
Evidence Level:Sensitive: C3 – Early Trials
Title:
Effect of Additional Trastuzumab in Neoadjuvant and Adjuvant Treatment for Patients with Resectable HER2-Positive Gastric Cancer
Excerpt:We performed a retrospective cohort study to compare chemotherapies with or without trastuzumab among human epidermal growth factor receptor 2-positive (HER2 +) locally advanced GC patients in the AT and NAT settings, respectively....AT combined with trastuzumab showed a better overall survival (OS) over chemotherapy alone (p = 0.023).
DOI:10.1245/s10434-020-09405-6
Evidence Level:Sensitive: C3 – Early Trials
Title:
A phase II study of trastuzumab with S-1 plus oxaliplatin for HER2-positive advanced gastric cancer (HIGHSOX study): Final report
Excerpt:We conducted an open-label, phase II trial in pts with chemo-naïve, HER2-positive AGC. Pts received S-1...oxaliplatin...trastuzumab...both OS and PFS were longer in pts with HER2 3+ (n=55) than in pts with 2+ (n=20) [OS, 25.9 vs.16.3 months; hazard ratio (HR), 0.59; 95% CI: 0.329–1.053; P=0.07; PFS, 9.8 vs. 7.0 months; HR, 0.72; 95% CI: 0.421–1.229; P=0.23].
Secondary therapy:oxaliplatin + tegafur/uracil
Evidence Level:Sensitive: C3 – Early Trials
Title:
158P - A phase II study of trastuzumab with S-1 plus oxaliplatin for HER2-positive advanced gastric cancer (HIGHSOX study): Final report (ID 275)
Excerpt:75 pts with a median follow up of 20.6 months, ORR was 70.7% (95% confidence interval (CI): 59.0–80.6) and the disease control rate was 93.3% (95% CI: 85.1–97.8)...OS and PFS (median) were 20.6 (95% CI: 15.9–29.2) and 8.8 (95% CI: 7.3–11.8) months...Tmab in combination with SOX exhibited promising therapeutic effects in pts with HER2-positive AGC.
Evidence Level:Sensitive: C3 – Early Trials
Title:
Combination of trastuzumab and taxane-containing intensified chemotherapy in first-line treatment of HER2-positive advanced gastric cancer
Excerpt:OS of the standard and intensified group were 11.1 months (95% CI 8.3-13.9) and 15.2 months (95% CI 12.7-17.7), respectively (p = 0.03).
DOI:10.1177/0300891620969823
Evidence Level:Sensitive: C3 – Early Trials
Title:
[Relationship of early tumor shrinkage and depth of response with the prognosis and treatment effect of trastuzumab combined with chemotherapy as first-line treatment in advanced gastric cancer patients with epidermal growth factor receptor 2 positive]
Excerpt:The objective response rate (ORR) of the 23 patients was 43.5% and the disease control rate (DCR) was 82.6%....The median overall survival (mOS) of ETS≥20% and ETS<20% were 26.8 months and 10.1 months, respectively, with statistical significance (P<0.001).
DOI:10.3760/cma.j.cn112152-20190213-00082
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab plus docetaxel and capecitabine as a first-line treatment for HER2-positive advanced gastric or gastroesophageal junction cancer: a phase II, multicenter, open-label, single-arm study
Excerpt:This phase II, multi-center, open-label, single arm study enrolled patients with HER2-positive AGC who had not received prior treatment for metastatic disease….The median PFS was 8.1 months (95% confidence interval [CI]: 5.6-12.8) and the median OS was 20.9 months (95% CI: 15.1-33.0). Response was evaluated in 59 patients. The ORR was 67.8%....We concluded that combination treatment with trastuzumab and DX was well-tolerated and highly effective...
Evidence Level:Sensitive: C3 – Early Trials
Title:
Second-line treatment in advanced gastric cancer: Data from the Spanish AGAMENON registry
Excerpt:PFS-2/PPS medians gradually increased in monoCT, 2.6/5.1 months; polyCT 3.4/6.3 months; ramucirumab+CT, 4.1/6.5 months; platinum-reintroduction, 4.2/6.7 months, and for the HER2+ subgroup in particular, trastuzumab+CT, 5.2/11.7 months.
DOI:10.1371/journal.pone.0235848
Evidence Level:Sensitive: C3 – Early Trials
Title:
Multicenter phase II study of SOX plus trastuzumab for patients with HER2 + metastatic or recurrent gastric cancer: KSCC/HGCSG/CCOG/PerSeUS 1501B
Excerpt:...to assess the efficacy and safety of T-mab + S-1 and oxaliplatin (T-SOX130) for HER2+ AGC or recurrent gastric cancer. T-SOX130 showed promising response and survival with a favorable safety profile and should be considered for patients with HER2+ AGC.
DOI:10.1007/s00280-019-03991-3
Evidence Level:Sensitive: C3 – Early Trials
Title:
A phase II study of trastuzumab with S-1 plus oxaliplatin for HER2-positive advanced gastric cancer (HIGHSOX)
Excerpt:This is the multi-central, phase II study that is conducted in 10 Japanese institutions. Patients with HER2-positive AGC received S-1...oxaliplatin...trastuzumab...Median OS, PFS, were estimated as 20.6 (95% CI.14.8–30.6) and 9.4(95% CI.7.4-14.7) months, respectively....Trastuzumab in combination with SOX showed promising activity with well-tolerated toxicities in patients with HER2-positive AGC as well as other platinum and FUs.
Secondary therapy:oxaliplatin + tegafur/uracil
DOI:10.1093/annonc/mdy282.051
Evidence Level:Sensitive: C3 – Early Trials
Title:
Updated analysis of a phase II study of SOX plus trastuzumab for the patients with HER2 positive advanced or recurrent gastric cancer: KSCC/HGCSG/CCOG/PerSeUS1501B
Excerpt:Median PFS, TTF and OS was 7.0 (95%C.I.: 5.5–14.1), 5.7 (95%C.I.: 4.6–7.0) and 27.7 (95%C.I.: 15.6–) months, respectively....HER-SOX130 demonstrates promising response and survival with avourable safety profile. HER-SOX130 should be considered for the patients with HER2-positive AGC.
Secondary therapy:oxaliplatin + tegafur/uracil
DOI:10.1093/annonc/mdy282.052
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab plus docetaxel and capecitabine for first-line treatment of Her2-positive advanced gastric cancer: A phase II, multi-center, open-label, single-arm study.
Excerpt:Combination of trastuzumab and docetaxel/capecitabine is a well-tolerated and highly effective regimen in patients with HER2-positive advanced gastric cancer
Evidence Level:Sensitive: C3 – Early Trials
Title:
Trastuzumab plus docetaxel and capecitabine for first-line treatment of Her2-positive advanced gastric cancer: A phase II, multi-center, open-label, single-arm study.
Excerpt:Combination of trastuzumab and docetaxel/capecitabine is a well-tolerated and highly effective regimen in patients with HER2-positive advanced gastric cancer
Evidence Level:Sensitive: C3 – Early Trials
New
Title:
Response to Trastuzumab Treatment and Number of Cycles in Her2-Positive Metastatic Gastric Cancer Survival
Excerpt:The median OS and PFS were significantly higher in those who demonstrated partial or complete response to trastuzumab combination treatment, and those who received more than 10 cycles of trastuzumab.
DOI:10.29271/jcpsp.2020.12.1279
Evidence Level:Sensitive: C3 – Early Trials
New
Title:
Two therapeutic regimens for advanced gastric carcinoma: DOS chemotherapy alone vs. trastuzumab combined with DOS
Excerpt:The HER-2-positive patients were treated with trastuzumab combined with DOS regimen,while the HER-2-negative patients were treated with DOS regimen alone….In Trastuzumab + DOS group and DOS group, the objective response rate (ORR) was 66.0% and 52.8%, respectively, and the disease control rate (DCR) was 94.3% and 90.6%, respectively....the R0 resection rate in Trastuzumab + DOS group was significantly higher than that in DOS group. The pathological response rate (≥ grade 1b) was 80.0% and 60.4%, respectively, in the two groups, which was obviously higher in Trastuzumab + DOS group than that in DOS group.
Evidence Level:Sensitive: C3 – Early Trials
New
Title:
Local and Central Evaluation of HER2 Positivity and Clinical Outcome in Advanced Gastric and Gastroesophageal Cancer-Results from the AGMT GASTRIC-5 Registry
Excerpt:Centrally confirmed HER2 positive patients receiving trastuzumab-based palliative first-line therapy showed a longer median overall survival compared to centrally HER2 positive patients not receiving trastuzumab (17.7 months (95% CI: 10,870-24,530) vs. 6.9 months (95% CI: 3.980-9.820), p = 0.016).
Evidence Level:Sensitive: C3 – Early Trials
New
Title:
Phase II Study of the Reuse of Trastuzumab with Docetaxel beyond Progression after First-Line Treatment in Second-Line Treatment for Unresectable, Metastatic Gastric Cancer (T-CORE1203)
Excerpt:We conducted this phase II study to assess whether trastuzumab plus docetaxel was effective for patients with previously treated advanced HER2-positive gastric cancer….Partial response was seen in 3 patients among the 26 evaluated patients. The overall response rate was at 11.5% (90% confidence interval 1.2%-21.8%). The median progression-free survival was 3.2 months, the 6-month survival rate was 85%, and the median overall survival was 11.6 months.
Evidence Level:Sensitive: C4 – Case Studies
Title:
Long-term survival after multidisciplinary treatments for HER2-positive advanced gastric cancer with multiple liver and lung metastases
Excerpt:We encountered a case of long-term survival after multidisciplinary treatments for HER2-positive advanced gastric cancer with multiple liver and lung metastases.
DOI:10.1186/s40792-023-01714-8
Evidence Level:Sensitive: C4 – Case Studies
Title:
Case Report: Durable Clinical Response to Third-Line Pyrotinib After Resistance to Trastuzumab in a Gastric Cancer Patient
Excerpt:CONTRADICTING EVIDENCE: A 49-year-old female was diagnosed with stage IV GC with liver and lung metastasis in July 2017. She underwent gastrostomy, and the immunohistochemistry (IHC) result of postoperative tissue demonstrated HER2 (3+). She received first-line treatment of trastuzumab (440 mg), oxaliplatin (200 mg), and S-1 (40 mg)....After progression, she subsequently received trastuzumab (440 mg) plus oxaliplatin (200 mg) as second-line treatment. However, the patient developed resistance to trastuzumab after 12 months of treatment.
Secondary therapy:oxaliplatin + gimeracil/oteracil/tegafur
DOI:https://doi.org/10.3389/fonc.2021.780577
Evidence Level:Sensitive: C4 – Case Studies
Title:
A Case of HER2 Positive Gastric Cancer That Was Highly Responsive to Fifth-Line Chemotherapy with Trastuzumab
Excerpt:A 76-year-old male underwent distal gastrectomy for gastric cancer and pathological findings showed Stage IV (T4a, N3a, M1, H0, P0, CY1) with HER2 positivity….Fifth-line chemotherapy with trastuzumab was administered. After 4 courses, the lung metastases reduced and the left adrenal metastasis shrank from 46 mm to 33 mm. These results were consistent with a partial response on the Response Evaluation Criteria in Solid Tumors.
Evidence Level:Sensitive: C4 – Case Studies
Title:
Prognostic benefit of conversion surgery for HER2 positive stage IV gastric cancer; a case series study of eleven patients treated with trastuzumab-based chemotherapy
Excerpt:We retrospectively investigated the medical records of the patients with HER2 positive (immunohistochemistry (IHC) 3+ or IHC2+/fluorescence in-situ hybridization (FISH) positive) stage IV gastric cancer who were treated with trastuzumab-based chemotherapy...chemotherapy was given every 3 weeks. Capecitabine 1000 mg/m2 or S-1 80 mg/m2 was given orally twice a day for 14 days followed by a 1-week rest. On day 1, Cisplatin 80 mg/m2 was intravenously administered....Response rate was 63.6%, and the median OS, since the start of trastuzumab-based chemotherapy of those 11 patients was 31.5 months...
Secondary therapy:cisplatin + capecitabine + tegafur/uracil
DOI:10.1186/s40792-020-00984-w
Evidence Level:Sensitive: C4 – Case Studies
New
Title:
[Long-Term Survival in a Patient with Stage ? Gastric Cancer Successfully Treated with Multidisplinary Treatment]
Excerpt:A man in his 60s who had epigastric pain was referred to our hospital and diagnosed with advanced type 3 gastric cancer with multiple liver metastases, cT4acN2cN1(H1), cStage Ⅳ(HER2 3+). He underwent chemotherapy using capecitabine, cisplatin(CDDP), and trastuzumab(T-mab)(XPT). The patient is alive without recurrence at 57 months after the initial treatment and 22 months after the last treatment.