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Association details:
| Biomarker: | HER-2 positive |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug Class: | HER2-targeted CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Published date:
11/27/2021
Excerpt:
Moreover, through the tumor-bearing model of the NOD-Prkdcem26cd52 Il2rgem26Cd22/Nju (NCG) mice, HER2 CAR-T cells showed signs of effectively preventing CRC progression in three different xenograft models. Notably, HER2 CAR-T cells displayed greater aggressiveness in HER2+ CRC in the patient-derived tumor xenograft (PDX) models and had potent immunotherapeutic capacity for mCRC in the metastatic xenograft mouse models.
DOI:
https://doi.org/10.1038/s41419-021-04100-0
