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    Association details:
    Biomarker:HER-2 overexpression
    Cancer:Gastric Cancer
    Drug:AT101 (CD19-targeted CAR-T immunotherapy)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Oncotarget
    Title:

    AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy

    Published date:
    06/07/2016
    Excerpt:
    ...we investigated the role of AT101 in synergetic efficacy with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell apoptosis.
    Secondary therapy:
    5-fluorouracil
    DOI:
    10.18632/oncotarget.9119