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    Association details:
    Biomarker:HER-2 overexpression
    Cancer:Esophageal Adenocarcinoma
    Drug:Enhertu (fam-trastuzumab deruxtecan-nxki) (Topoisomerase I inhibitor, HER2-targeted antibody-drug conjugate)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    Source:
    NCCN
    Published date:
    03/09/2021
    Excerpt:
    Esophageal and esophageal junction cancer Gastric cancer: Preferred regimens...Fam-trastuzumab deruxtecan-nxki for her2 overexpression positive adenocarcinoma
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrials.gov
    Title:

    Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer

    Excerpt:
    ...- Pathologically documented adenocarcinoma of the stomach (clinical stage before surgery of AJCC I-III), gastroesophageal junction, or lower oesophagus (to include Type I Siewert only), with HER2 overexpression (IHC 3+ or IHC 2+/ISH+) based on local tissue testing results....
    Trial ID:
    DECIPHER