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    Association details:
    Biomarker:HER-2 overexpression
    Cancer:Breast Cancer
    Drug:simvastatin (HMG-CoA reductase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Cancer Res Treat
    Title:

    Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Advanced Local Breast Cancer

    Published date:
    03/09/2021
    Excerpt:
    The addition of 40 mg simvastatin may improve the efficacy of FAC in LABC patients with HER-2 overexpression.
    Secondary therapy:
    FAC
    DOI:
    10.4143/crt.2020.1024