Evidence Level:Sensitive: A2 - Guideline
New
Excerpt:Breast Cancer: HER2-Negative and Postmenopausal or Premenopausal Receiving Ovarian Ablation or Suppression…Preferred Regimens…First-Line Therapy...Selective estrogen receptors modulator (tamoxifen or toremifene)...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer
Excerpt:...• Women 16 years of age and above• New diagnosed histologically confirmed breast cancer• Premenopausal as defined by the following criteria: o gonadotrophin levels (luteinizing hormone and follicle stimulating hormone) and oestradiol levels within the local laboratory’s reference range for premenopausal females• Ability to provide menstrual cycle information• ER positive (Allred ≥3)• PgR positive (Allred ≥3)• HER2 negative (IHC 1+ or 2+ and HER2/CEP17 ratio of cceptable methods of contraception.b. ...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Efficacy of High Dose Tamoxifen to Advanced Hormone Receptor-High Expressed Breast Cancer
Excerpt:...ER ≥60% and PR≥60%) on primary tumour at diagnosis/on biopsy of metastasis Histological confirmation of HER2 negative breast cancer on primary tumour at diagnosis/on biopsy of a metastasis The disease-free time of relapsed patients is more than 12 months Once received standard hormone treatment and progressed Clinical or histological confirmation of metastatic or locally advanced disease...
More C2 evidence
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Concordance of the IHC4 Score Performed in Local or Central Laboratory to Endopredict in ER+/HER2- Breast Cancer
Excerpt:...HER2-negative tumor by IHC (score 0 or 1+) and/or fluorescent in situ hybridization (FISH)/chromogenic in situ hybridization (CISH) negative (local assessment) 5....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast Cancer
Excerpt:...- HER2 negative status is determined by:...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Impact of Endocrine Therapy, Menstrual Cycle, PAM50, Ki67 on Treatment Decisions in HR+ and HER2- Breast Cancer
Excerpt:...- Estrogen receptor (ER)-/ or Progesterone receptor (PR)- positive and HER2-negative...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
CLEAR-B: Cancer Landscape - Early Adjuvant Retrospective Registry - Breast Cancer
Excerpt:...- Female patients with a first primary diagnosis of hormone receptor-positive, HER2- negative unilateral early breast cancer for whom an endocrine treatment is indicated...
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen
Excerpt:...- Premenopausal and postmenopausal female breast cancer patient with histological proven ER and/or PR positive*, HER2 negative breast cancer (based on the most recent assessment of ER and PR status from primary breast cancer or from recurrent or metastatic disease)....
Evidence Level:Sensitive: C2 – Inclusion Criteria
New
Title:
A Multicenter Trial Assessing the Efficacy and Safety of tamOxifen Plus LY2228820 in Advanced or Metastatic Breast Cancer Progressing on aromatasE Inhibitors
Excerpt:...- 18 40 mIU/mL and estradiol 10% by IHC) and HER2-negative status (IHC 0 or 1+ or 2+ and FISH negative) on the last biopsy or surgical specimen available....