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Association details:
| Biomarker: | HER-2 negative |
|---|---|
| Cancer: | HER2 Negative Breast Cancer |
| Drug: | letrozole (Aromatase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
Invasive Breast Cancer: HER2-Negative and postmenopausal or premenopausal receiving ovarian ablation or suppression:...Preferred Regimens…First-Line Therapy...Non-steroidal aromatase inhibitor (anastrozole, letrozole)...
Source:
Title:
Neoadjuvant Endocrine Therapy in Breast Cancer
Excerpt:
...ER-positive (≥50%), PgR-positive (≥50% ), HER2-negative, and previously untreated, non-metastatic primary invasive BC....
Trial ID:
Source:
Title:
Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women
Excerpt:
...Patient has HER2 negative breast cancer defined as a negative in situ hybridization test or an IHC status of 0 or 1+ as per local laboratory testing...
Trial ID:
More C2 evidence
Source:
Title:
Neo-adjuvant Chemotherapy With Letrozole in Patients With Estrogen Receptor Positive/HER-2 Negative Breast Cancer
Excerpt:
...- HER2-negative by ASCO/CAP guideline...
Trial ID:
Source:
Title:
Pre-Operative Study of PF-4691502 With Letrozole Compared To Letrozole Alone In Patients With Early Breast Cancer
Excerpt:
...- Postmenopausal women with diagnosis of breast cancer, metastatic disease or locally advanced disease / Estrogen Receptor positive and HER-2 negative / candidate to receive Letrozole...
Trial ID:
Source:
Title:
Neoadjuvant Dalpiciclib Plus Letrozole for HR+/HER2- Breast Cancer
Excerpt:
......
Trial ID:
Source:
Title:
Letrozole in Treating Postmenopausal Women With Stage I, II or III Breast Cancer That Can Be Removed by Surgery
Excerpt:
...- HER2-negative tumor by Herceptest (0 or +1) OR HER2...
Trial ID:
Source:
Title:
Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer
Excerpt:
...- HER2 negative...
Trial ID:
Source:
Title:
A Study of ARV-471 (PF-07850327) Plus Palbociclib Versus Letrozole Plus Palbociclib in Participants With Estrogen Receptor Positive, Human Epidermal Growth Factor Negative Advanced Breast Cancer
Excerpt:
......
Trial ID:
Source:
Title:
Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer
Excerpt:
...- HER2-negative breast cancer based on the most recent tumor biopsy and documented by a local laboratory or medical record....
Trial ID:
Source:
Title:
A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer
Excerpt:
...- The tumor must be HER2 negative (negative IHC or FISH)...
Trial ID:
Source:
Title:
Analysis of Letrozole in Patients With Operable Hormone Receptor Positive, HER2 Negative Breast Cancer
Excerpt:
...Tissue samples from patients with early-stage hormone receptor-positive HER2-negative breast cancer will be collected to compare differences....
Trial ID:
Source:
Title:
Phase II/III Study of SPH4336 Combined With Letrozole vs Placebo Combined With Letrozole in First-line Treatment of Breast Cancer
Excerpt:
...Patients with locally advanced or metastatic breast cancer who are unable to receive radical surgeries/other local therapies, with hormone receptor positive and human epidermal growth factor receptor 2 negative confirmed by tumor histopathology and molecular pathology....
Trial ID:
Source:
Title:
Select the Appropriate Population for Adding CDK4/6i to Neoadjuvant Endocrine Therapy
Excerpt:
......
Trial ID:
Source:
Title:
A Randomized Study Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBC
Excerpt:
...with estrogen receptor positive (>10%) on IHC staining and HER2 negative (IHC 0+/1+, or IHC 2+ plus FISH negative)...
Trial ID:
Source:
Title:
Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.
Excerpt:
...Patient has HER2-negative breast cancer defined as a negative in situ hybridization test or an IHC status of 0, 1+ or 2+....
Trial ID:
Source:
Title:
Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase Inhibitors
Excerpt:
...- Postmenopausal women with hormone receptor-positive and HER-2 negative breast cancer...
Trial ID:
Source:
Title:
Clinical Study for the Treatment of Breast Cancer: the Patient Will Receive Afatinib Plus Letrozole or Letrozole Alone
Excerpt:
...- HER2 negative breast cancer....
Trial ID:
Source:
Title:
An unblinded clinical trial for the treatment of a particular subtype of postmenopausal breast cancer where the patient will receive at random either Afatinib plus Letrozole or Letrozole alone Ensayo clínico para el tratamiento de pacientes postmenopáusicas con un subtipo particular de cáncer de mama en el que las pacientes podrán recibir (mediante asignación al azar) Afatinib más Letrozol o Letrozol solo.
Excerpt:
...4.HER2 negative breast cancer. ...
Trial ID:
Source:
Title:
A single-arm, multicenter, exploratory clinical study of CDK4/6 inhibitor combined with letrozole in preoperative treatment of stage II-III HR+, HER2- breast cancer (Luminal type)
Excerpt:
...Pathological examination confirmed HR+, HER2- invasive breast cancer; estrogen receptor (ER) positive (>10%), progesterone receptor (PR) positive (>1%), HER2 negative. ...
Trial ID:
