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Association details:
| Biomarker: | HER-2 L768S |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Dual Characteristics of Novel HER2 Kinase Domain Mutations in Response to HER2-Targeted Therapies in Human Breast Cancer
Excerpt:
Functional analysis of lapatinib-resistant HER2 mutation K753E in HER2-positive breast cancer....While L768S and V773L have similar colony number with K753E after being treated with trastuzumab and lapatinib, the drugs significantly decreased the number of colonies formed, and we conclude that L768S and V773L mutations were sensitive toward trastuzumab and lapatinib treatment.
DOI:
10.1158/1078-0432.CCR-15-3036
