^
Association details:
| Biomarker: | HER-2 L755P |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
Excerpt:
...ERBB2-L755S (IC50>2 µM), ERBB2-L755P (IC50>1.5 µM)...caused strong lapatinib resistance.
DOI:
10.1371/journal.pone.0026760
