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Association details:
| Biomarker: | HER-2 G780_P781dupGSP |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Irene (pyrotinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib
Published date:
07/31/2020
Excerpt:
Patient 5 was a 60 year-old female initially presenting with advanced lung adenocarcinoma...The result of NGS revealed HER2 insertion mutation (p.G780_P781dupGSP) (Figures 1B,D)...Then the patient took pyrotinib as the third-line therapy with the best response of PR, and PFS was 12.5 months until November 30, 2019.
DOI:
10.3389/fonc.2020.01162
