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Association details:
| Biomarker: | HER-2 G778_S779insCPG |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib
Published date:
07/31/2020
Excerpt:
Patient 4 was a 65 year-old female never-smoker who was diagnosed with advanced lung adenocarcinoma...Then she received nivolumab immunotherapy as the second-line treatment and confirmed progressive disease (PD) after eight cycles with new onset of bone and brain metastases...The result of NGS of re-biopsy tissue revealed HER2 exon 20 insertion mutation (p.G778_S779insCPG)...
DOI:
10.3389/fonc.2020.01162
