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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Poziotinib inhibits HER2 mutant-driven therapeutic resistance and multi-organ metastasis in breast cancer

Published date:
06/23/2022
Excerpt:
The most highly recurrent HER2 mutant, L755S, was particularly resistant to neratinib but sensitive to the pan-HER TKI poziotinib, alone or in combination with fulvestrant....Similar therapeutic effects of poziotinib were observed in both an engineered HER2L755S MCF7 model and a patient-derived xenograft harboring a HER2G778_P780dup mutation. Overall, these findings support the need for clinical evaluation of poziotinib for the treatment of HER2 mutant metastatic breast cancer.
DOI:
10.1158/0008-5472.CAN-21-3106