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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

897 AST-301, a pDNA-based cancer vaccine encoding HER2-ICD, enhances anti-tumor effect of HER2-ADC in a HER2-expressed gastric cancer xenograft model

Published date:
11/04/2023
Excerpt:
This study was conducted to evaluate an synergistic effect and immune response of the combination of AST-301 and HER2-ADC in HER2-expressed gastric cancer xenograft model….It was showed that adding AST-301 to LCB01 or Kadcyla inhibited a tumor growth based on TGI rate at days 25; AST-301 combining with LCB01 vs LCB01 mono (52% vs 43%), AST-301 combining with Kadcyla vs Kadcyla mono (43% vs 34%). It was also observed or that myeloid-derived suppressor cells (MDSCs) elevation was inhibited in tumor site in the combination groups of all ADCs with AST-301 compared to control group....With combining AST-301 and HER2 ADCs, it was demonstrated that antitumor effects were likely synergistic in athymic mouse model.
DOI:
http://dx.doi.org/10.1136/jitc-2023-SITC2023.0897