^
Association details:
| Biomarker: | HER-2 expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | MT-5111 (HER2 inhibitor, Protein synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
MT-5111, a novel HER2 targeting engineered toxin body, under clinical development to overcome mechanisms of resistance to existing HER2 targeted therapies
Excerpt:
Specifically, T-DM1 resistant cell lines with moderate HER2 expression (JIMT-1 breast cancer and SNU-216 gastric cancer lines) were sensitive to MT-5111…
DOI:
https://doi.org/10.1158/1538-7445.SABCS19-P1-18-35
