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Association details:
| Biomarker: | HER-2 amplification |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | JBJ-08–178–01 (HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
Published date:
04/15/2022
Excerpt:
The compound showed strong antitumoral activity in HER2-mutant or amplified cancers in vitro and in vivo….Taken together, the dual activity of JBJ-08–178–01 as a selective inhibitor and destabilizer of HER2 represents a combination that may lead to better efficacy and tolerance in patients with NSCLC harboring HER2 genetic alterations or amplification.
DOI:
https://doi.org/10.1158/0008-5472.CAN-21-2693
