^
Association details:
| Biomarker: | HER-2 amplification |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | torkinib (PP242) (mTOR inhibitor, mTORC2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs
Published date:
02/28/2011
Excerpt:
...a subset of cell lines harbouring HER2 amplification showed increased sensitivity to PP242 but not everolimus irrespective of the PIK3CA mutation status.
DOI:
10.1038/onc.2011.42
