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Association details:
| Biomarker: | HER-2 A775_G776insYVMA |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Irene (pyrotinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Comparison the anti-tumor effect of pyrotinib, afatinb and T-DM1 in lung cancer organoids and PDX models with HER2 mutation.
Published date:
05/16/2018
Excerpt:
Patient-derived organoids and xenografts were established from a 42-year-old female with HER2-A775_G776YVMA-inserted advanced lung adenocarcinoma…The in vivo PDX model study showed that pyrotinib(mouse,80mg/kg,adopted from clinical trial recommended dose) showed a significantly superior anti-cancer effect than afatinib of 15 mg/kg (p = 0.0471), T-DM1 of 10 mg/kg.
