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Association details:
| Biomarker: | HAVCR2 deletion |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | docetaxel (Tubulin polymerization promoter, Microtubule stabilizer) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2340P - T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim3) in breast cancer and the impact on penetration of blood brain barrier by cancer cells
Published date:
10/16/2023
Excerpt:
In the cerebral endothelial cell invasion assay, we found that Tim3 knockdown in both MCF-7 and MDA-MB-231 resulted in a significantly reduced invasion of the breast cancer cells through the endothelium (31±8 vs 24±8 for MCF7, p=0.018; 211±48 vs 142±54 for MDA-MB-231, p<0.001, WT and Tim3kd respectively)...Tim3 has a marked influence on the barrier functions, adhesiveness and the sensitivity to docetaxel of breast cancer cells. Loss of Tim3 in breast cancer cells reduces tumour cell's penetration of cerebral endothelium.
