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Association details:
| Biomarker: | H2BC8 underexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | bortezomib (Proteasome inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Exosomal mRNAs and lncRNAs involved in multiple myeloma resistance to bortezomib
Published date:
12/29/2020
Excerpt:
qPCR was used to evaluate the levels of exosomal FFAR1, SP9, HIST1H2BG...qPCR results verified the increases in FFAR1 and SP9 and decreases in HIST1H2BG and ITIH2 in Btz-resistant patient-derived exosomes...Our study reveals significant dysregulation of exosomal RNA components in the Btz-resistant group of MM patients as well as several mRNAs that may be used as biomarkers of prognosis of MM patients that are resistant to Btz.
DOI:
10.1002/cbin.11540