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Association details:
| Biomarker: | GSTP1 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) + cyclophosphamide (Alkylating agent) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Predictive and Prognostic Significance of mRNA Expression and DNA Copies Aberrations of ERCC1, RRM1, TOP1, TOP2A, TUBB3, TYMS, and GSTP1 Genes in Patients with Breast Cancer
Published date:
02/04/2023
Excerpt:
According to our results, the presence of a high level of GSTP1 in a tumor biopsy is associated with the low efficiency of the NAC CP scheme (p = 0.05). The presence of RRM1 deletion is associated with complete and partial regression, as for the TOP1 and TUBB3 genes (p < 0.05). Higher rates of metastatic survival are associated with a high level of expression and amplification of the GSTP1 gene (log-rank test p = 0.02 and p = 0.05).
DOI:
10.3390/diagnostics12020405
