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Association details:
| Biomarker: | GSTM1 expression + GSTM5 expression |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Glutathione S-transferase M subfamily in TMZ-resistant glioblastoma cells
Published date:
10/01/2018
Excerpt:
In our study, we generated TMZ-resistant glioblastoma GBM8401 cells (GBM8401-TMZ-R) over a 130-day period…We found GBM8401-TMZ-R cells with significantly higher MGMT expression and increased TMZ tolerance...Surprisingly, GBM8401-TMZ-R cells showed higher GST activity and increased GSTM1 and GSTM5 protein levels than GBM8401...From these results, we theorized that certain GST proteins may play a key role in TMZ-resistant glioblastoma cells.
DOI:
https://doi.org/10.1093/annonc/mdy304.031