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Association details:
| Biomarker: | GPX4 expression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | erastin (Ferroptosis inducer) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer
Published date:
01/22/2021
Excerpt:
In this study, we demonstrate that mediators of ferroptosis SLC7A11, SLC3A2 and GPX4 are expressed in treatment-resistant prostate cancer. We further demonstrate that treatment-resistant prostate cancer cells are sensitive to two ferroptosis inducers, erastin and RSL3.
DOI:
10.1158/0008-5472.CAN-20-3477
