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Association details:
| Biomarker: | GPC3 expression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | ZW251 (Topoisomerase I inhibitor, GPC-3-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload
Published date:
04/04/2023
Excerpt:
ZW251 exhibited potent and target-specific cytotoxicity in a panel of HCC cells cultured either in monolayer or as 3D spheroids...A single administration of ZW251 resulted in robust tumor growth inhibition of a large panel of CDX and PDX models representing a range of GPC3-expression. Overall, these results support the potential of ZW251 as a novel therapeutic agent against GPC3-bearing cancers.
DOI:
10.1158/1538-7445.AM2023-2658
