SubMap analyses confirmed the indicator role of GOLM1 in predicting immunotherapy response in UVM….We also predicted the potential responders with the SubMap analysis of a melanoma cohort receiving anti-PD-1 and anti-CTLA4 therapies, demonstrating that patients in the HEXP group are more likely to be sensitive to both anti-CTLA4 and anti-PD-1/PD-L1 therapies....Taken together, GOLM1 is a novel prognostic marker, and it can be employed to predict the overall survival outcomes and treatment responses of anti-PD-1/PD-L1 and anti-CTLA4 therapies for UVM patients.